About the unfolding of a Hopf-zero singularity Freddy Dumortier Universiteit Hasselt, Campus Diepenbeek, Agoralaan-Gebouw D, B-3590, Diepenbeek, Belgium E-mail: freddy.dumortier@uhasselt.be Santiago Ib\'a\~nez Departamento de Matem\'aticas, Universidad de Oviedo, Avda. Calvo Sotelo s/n, 33007 Oviedo, Spain E-mail: mesa@uniovi.es Hiroshi Kokubu Department of Mathematics/JST-CREST, Kyoto University, Kyoto 606-8502, Japan E-mail: kokubu@math.kyoto-u.ac.jp Carles Sim\'o Departament de Matem\`atica Aplicada i An\`alisi, Universitat de Barcelona Gran Via, 585, 08071 Barcelona, Spain E-mail: carles@maia.ub.es Abstract We study arbitrary generic unfoldings of a Hopf-zero singularity of codimension two. They can be written in the following normal form: \[ \left\{\begin{array}{l} x'=-y+\mu x-axz+A(x,y,z,\lambda,\mu) \\ y'=x+\mu y-ayz+B(x,y,z,\lambda,\mu) \\ z'=z^2+\lambda+b(x^2+y^2)+C(x,y,z,\lambda,\mu), \end{array} \right. \] where $A$, $B$, $C$ are $C^\infty$ or $C^\omega$ and of order $O(\|(x,y,z,\lambda,\mu)\|^3)$. Moreover we focus on the most interesting case, namely, the topological type of codimension two characterized by the open conditions $a>0$ and $b>0$. At second order the above family is integrable for $\mu=0$ and, when $\lambda < 0$, there exist on the vertical axis two saddle-focus equilibrium points with different stability indices. Their respective two-dimensional invariant manifolds coincide and form an ellipsoid. Inside, the equilibrium points are connected by a heteroclinic orbit along the vertical axis. Such configuration can be destroyed by higher order terms and therefore homoclinic and heteroclinic orbits can appear. The saddle-focus homoclinic orbits will satisfy the Shilnikov conditions for $0